RADIO PROGRAMME

751 Coley's Toxin, Cancer and Immunology Archive

August 7, 2010


http://www.peoplespharmacy.com/siteassets/PP-751B.mp3

 http://www.peoplespharmacy.com/siteassets/MatzingerFull.mp3

Dr. William Coley was a cancer surgeon at the turn of the 20th century. In an effort to improve the treatment he could offer his patients, he created a toxin that made them really sick. If they recovered from their fever, however, they were often cured of their sarcomas.

A century later, cancer researchers are taking a new look at Coley's toxin and how it might help us understand spontaneous remissions and the role of the immune system. In exploring this topic, we encounter an innovative immunologist who has developed a new paradigm for how the immune system works.

Guest: Uwe Hobohm, PhD, is a cell biologist and Professor of Bioinformatics at the University of Applied Sciences in Giessen, Germany. He has worked at the European Molecular Biology Laboratory in Heidelberg and at F. Hoffmann-La Roche in Basel. He is the author of Healing Heat: An Essay on Cancer Immune Defence.
http://bioinfo.tg.fh-giessen.de/pamp-cancer/

Polly Matzinger, PhD, is an ex-Playboy bunny turned scientist. At the National Institute of Allergy and Infectious Diseases, she is section head of the Ghost Lab, more formally known as the section on T cell tolerance and memory of the Laboratory of Cellular and Molecular Immunology. In her private life, she trains award-winning sheep dogs. The photo is of Polly and her dog Annie.

This is the first in a 3-part series on cancer and the immune system.

Truly fascinating and engaging. As an analytical LC-MS chemist, i too struggle with making useful analogies to convey science to laypeople whose eyes glaze with things they don't [wish to?] comprehend. Ms. Matzinger perceptively and intuiitively nails this. Dendritic cells as the Pacmen/sheepdogs of immune response. what a concept!! at any level 6th grade or otherwise. i wish her and colleagues in this arena well, for all to benefit.